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- Title
Clinicopathological findings of canine seborrhoeic keratosis with comparison to pigmented viral plaques.
- Authors
Bradley, Charles W.; Luff, Jennifer A.; Mauldin, Elizabeth A.
- Abstract
Background Seborrhoeic keratoses ( SKs) are common benign epidermal neoplasms in humans and are rarely diagnosed in the dog. These circumscribed, raised, variably pigmented plaques arise in middle aged to older humans, with a focal or multicentric distribution; although common, the underlying cause of these lesions is not known. Although less common in the dog, the lesions are similar and have features that overlap with papillomavirus-associated pigmented viral plaques. Hypothesis/Objectives Seborrhoeic keratoses in the dog are negative for canine papillomavirus. Animals Eleven cases of SK from a 12 year period were reviewed. Methods This was a retrospective study of the histopathological findings and case histories. Complete clinical records following collection of the skin biopsy were available in five of 11 cases. Immunohistochemistry was performed for all cases; PCR analysis was carried out for papillomavirus in six cases. Results Histologically, SKs had an exophytic to mildly endophytic epidermal proliferation, creating a papillomatous to acanthotic, hyperkeratotic, frequently pigmented plaque. There was an absence of hypergranulosis or viral cytopathic effect; PCRs for canine papillomavirus within the formalin-fixed paraffin-embedded skin biopsies were negative. No breed, sex or site predilection was recognized. The mean age at biopsy of the lesions was 8.8 years (range 5-14 years). Conclusions and clinical importance Histopathological features and negative papillomavirus status distinguish SK as an important differential diagnosis for pigmented viral plaques in dogs.
- Subjects
KERATOSIS; PAPILLOMAVIRUSES; HISTOPATHOLOGY; POLYMERASE chain reaction; DOG diseases; SKIN tumors
- Publication
Veterinary Dermatology, 2013, Vol 24, Issue 4, p432
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/vde.12039