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- Title
Molecular Evaluation of Vp1 Coding Region of Foot and Mouth Disease Virus Circulating in Pakistan.
- Authors
Ali, Waqas; Habib, Mudasser
- Abstract
Foot-and-mouth disease (FMD) is an extremely contagious viral disease of cloven-hoofed animals. In Pakistan, this disease causes huge losses to economy. However, the reports on its selection and evolutionary pathways are rare. In present study, 336 strains of serotype O (n = 178), A (n = 82) and Asia 1 (n = 76) were downloaded from NCBI database that mainly belonging to Pakistan, along with three vaccinal strains. Phylogenetic analysis (maximum likelihood) showed that lineages Pan Asia II, An Iran-05, and Group VII within serotype O, A and Asia 1 are causing majority of the outbreaks in the Pakistan during recent years. Moreover, only one residue of VP1 region was under positive selection pressure for serotype A (position 141) located in known critical antigenic region but as a whole protein was under negative selection pressure for serotype O, A and Asia 1. Therefore, under mass vaccination campaigns and drastic environmental conditions strains under negative selection has the ability to make escape mutants.
- Subjects
PAKISTAN; ASIA; FOOT &; mouth disease; FOOT &; mouth disease virus; ANIMAL diseases; COMMUNICABLE diseases; VIRUS diseases; ETIOLOGY of diseases
- Publication
Sarhad Journal of Agriculture, 2018, Vol 34, Issue 4, p979
- ISSN
1016-4383
- Publication type
Article
- DOI
10.17582/journal.sja/2018/34.4.979.985