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- Title
Improving cancer stem cells killing in malignant melanoma.
- Authors
Bergamaschi, Daniele
- Abstract
In this article from the British Journal of Dermatology, the authors explore the potential of targeting specific cancer stem cells to improve the effectiveness of BRAF inhibition in melanoma. They developed nonadherent three-dimensional spheroid models called melanospheres from malignant melanoma cell lines and found that they closely resemble the spatial complexity of human melanoma. The authors also identified the expression of the CD20 protein in a subset of melanoma cell lines, which may be involved in resistance to current targeted therapies. They suggest that a licensed anti-CD20 monoclonal antibody called rituximab could be beneficial in targeting and killing metastatic melanoma cells that are refractory to BRAF inhibition. Further research is needed to explore the potential of targeting CD20 in combination with other therapies.
- Subjects
CANCER stem cells; CANCER cells; REGULATORY B cells; MELANOMA
- Publication
British Journal of Dermatology, 2024, Vol 190, Issue 5, p615
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1093/bjd/ljae035