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- Title
Effect of cholecalciferol supplementation on hand grip strength, walking speed, and expression of vitamin D receptor, interleukin‐6, and insulin‐like growth factor‐1 in monocyte in pre‐frail older adults: A randomized double‐blind placebo‐controlled trial
- Authors
Dwimartutie, Noto; Setiati, Siti; Tamin, Tirza Z.; Prijanti, Ani Retno; Harahap, Alida R.; Purnamasari, Dyah; Harimurti, Kuntjoro; Pramantara, I Dewa Putu; Suwarto, Suhendro; Kojima, Taro
- Abstract
Aim: To investigate the effect of cholecalciferol supplementation on hand grip strength, walking speed, and expression of vitamin D receptor (VDR), interleukine‐6 (IL‐6) and insulin‐like growth factor‐1 (IGF‐1) in monocyte in pre‐frail older adults. Methods: We conducted a randomized double‐blinded placebo‐controlled clinical trial for 12 weeks, involving 120 pre‐frail older adults who were randomized to the cholecalciferol group (cholecalciferol 4000 IU/day) or the placebo group. All subjects were given calcium lactate 500 mg/day. Hand grip strength and walking speed, as primary outcomes, were analyzed using intention‐to‐treat analysis. The expression of VDR, IGF‐1 and IL‐6 in monocytes, as secondary outcomes, were analyzed using per‐protocol analysis. Results: After a 12‐week intervention, there was a significant increase in serum 25(OH)D levels in both groups, with the increase being higher in the cholecalciferol group than in the placebo group (49.05 vs. 24.01 ng/mL; P < 0.001). No statistically significant differences were observed in hand grip strength (P = 0.228) and walking speed (P = 0.734) between the groups. There were no differences in the expression of VDR (P = 0.513), IL‐6 (P = 0.509), and IGF‐1 (P = 0.503) monocytes between the groups. Conclusions: Cholecalciferol supplementation for 12 weeks increased serum 25(OH)D levels among pre‐frail older adults. However, it did not improve hand grip strength and walking speed, and nor did it change the expression of VDR, IL‐6, and IGF‐1 in monocytes. Geriatr Gerontol Int 2024; 24: 554–562.
- Subjects
MONOCYTES; PLACEBOS; RESEARCH funding; BLIND experiment; TREATMENT effectiveness; RANDOMIZED controlled trials; CHOLECALCIFEROL; GENE expression; WALKING speed; SOMATOMEDIN; DIETARY supplements; GRIP strength; CELL receptors; VITAMIN D; INTERLEUKINS
- Publication
Geriatrics & Gerontology International, 2024, Vol 24, Issue 6, p554
- ISSN
1444-1586
- Publication type
Article
- DOI
10.1111/ggi.14881