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- Title
Immune responses and disease biomarker long-term changes following COVID-19 mRNA vaccination in a cohort of rheumatic disease patients.
- Authors
Zesheng An; Figueroa-Parra, Gabriel; Xian Zhou; Yanfeng Li; Jaquith, Jane; McCarthy-Fruin, Kathleen; Sletten, Jennifer; Warrington, Kenneth J.; Weyand, Cornelia; Crowson, Cynthia S.; Chumsri, Saranya; Knutson, Keith L.; Sanchez-Rodriguez, Alain; Thanarajasingam, Uma; Duarte-García, Alí; Hu Zeng
- Abstract
Introduction: The longitudinal responses towards multiple doses of COVID-19 mRNA vaccines in patientswith systemic autoimmune diseases remain incompletely understood. While observational studies suggested the safety of COVID-19 mRNA vaccines in rheumatic disease patients, laboratory evidence is lacking. Methods: Here we evaluated seroreactivity, clinical manifestions, and multiple disease biomarkers after 2 or 3 doses of COVID-19 mRNA vaccines in a cohort of patients with rheumatic diseases. Results: Most patients generated high SARS-CoV-2 spike-specific neutralizing antibodies comparable to those in healthy controls after 2 doses of mRNA vaccines. The antibody level declined over time but recovered after the third dose of the vaccine. Patients with systemic lupus erythematosus (SLE) or psoriatic arthritis (PsA) remained without significant flares post-vaccination. The changes in anti-dsDNA antibody concentration and expression of type I interferon (IFN) signature genes were highly variable but did not show consistent or significant increases. Frequency of double negative 2 (DN2) B cells remained largely stable. Discussion: Our data provide experimental evidences indicating the efficacy and safety of repeated COVID-19 mRNA vaccination in rheumatic disease patients.
- Subjects
RHEUMATISM; COVID-19 vaccines; IMMUNE response; TYPE I interferons; PSORIATIC arthritis
- Publication
Frontiers in Immunology, 2023, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2023.1224702