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- Title
First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.
- Authors
Chabala, Chishala; Jacobs, Tom G; Moraleda, Cinta; Ndaferankhande, John M; Mumbiro, Vivian; Passanduca, Alfeu; Namuziya, Natasha; Nalwanga, Damalie; Musiime, Victor; Ballesteros, Alvaro; Domínguez-Rodríguez, Sara; Chitsamatanga, Moses; Cassia, Uneisse; Nduna, Bwendo; Bramugy, Justina; Sacarlal, Jahit; Madrid, Lola; Nathoo, Kusum J; Colbers, Angela; Burger, David M
- Abstract
Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.
- Subjects
UGANDA; ZAMBIA; MOZAMBIQUE; ZIMBABWE; ANTIBIOTICS; DRUG therapy for tuberculosis; HIV-positive persons; PNEUMONIA; HIV infections; ETHAMBUTOL; GLOMERULAR filtration rate; RESEARCH; CO-trimoxazole; PREDNISOLONE; BODY weight; BLOOD plasma; MULTIVARIATE analysis; PYRAZINAMIDE; MULTIPLE regression analysis; PATIENTS; ANTIRETROVIRAL agents; BLOOD collection; HOSPITAL admission &; discharge; SEVERITY of illness index; ISONIAZID; ANTITUBERCULAR agents; RESEARCH funding; VALGANCICLOVIR; DESCRIPTIVE statistics; RIFAMPIN; CHILDREN
- Publication
Journal of the Pediatric Infectious Diseases Society, 2023, Vol 12, Issue 11, p581
- ISSN
2048-7193
- Publication type
Article
- DOI
10.1093/jpids/piad088