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- Title
Sex-related influence of angiotensin-converting enzyme polymorphisms on fibrosis progression due to recurrent hepatitis C after liver transplantation.
- Authors
Fabris, Carlo; Toniutto, Pierluigi; Bitetto, Davide; Minisini, Rosalba; Fornasiere, Ezio; Smirne, Carlo; Pirisi, Mario
- Abstract
Experimental evidence and clinical studies suggest that the renin–angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) allelic variants, modulating angiotensin II generation, could affect the outcome of recurrent hepatitis C after liver transplantation, via several metabolic pathways. Forty-five (29 men) recipients, with a median histological follow-up of 60 months after orthotopic liver transplantation (OLT), were studied. ACE gene I/D polymorphism was assessed by means of a polymerase chain reaction procedure. Fibrosis progression was evaluated annually during the follow-up. Weight gain 1 year post-OLT (defined as an increase in body mass index, BMI, of >0.5 kg/m2) was significantly more common among D/* carriers (22/22 vs. 16/23, P < 0.005); patients who 1 year after OLT had an increase in their BMI value of >0.5 kg/m2 more frequently had a triglycerides/cholesterol ratio of ≤ 0.7 (16/22 vs. 8/23, χ-squared test P < 0.02). This association was stronger in men. Female D/D homozygotes had the highest probability of showing significant liver fibrosis (7/10) in comparison with men (11/29) and I/* women (1/6) ( P < 0.01). In patients with recurrent hepatitis C, carriers of the D allele appeared to gain more weight after liver transplantation, and in male liver recipients, the D allele was associated with a peculiar lipid profile that was associated with a slower rate of allograft fibrosis progression. Among female recipients, carriage of the D allele may favor more severe allograft fibrosis.
- Subjects
ANGIOTENSINS; CHEMICAL inhibitors; FIBROSIS; GENETIC polymorphisms; TRANSPLANTATION of organs, tissues, etc.; POLYMERASE chain reaction
- Publication
Journal of Gastroenterology, 2007, Vol 42, Issue 7, p543
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s00535-007-2040-1