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- Title
Cost effectiveness of day 5 G-CSF (Lenograstim<sup>®</sup>) administration after PBSC transplantation: results of a SFGM-TC randomised trial.
- Authors
Valteau-Couanet, D.; Faucher, C.; Aupérin, A.; Michon, J.; Milpied, N.; Boiron, J. M.; Bourhis, J. H.; Gisselbrecht, C.; Vernant, J. P.; Pinna, A.; Bendahmane, B.; Delabarre, F.; Benhamou, E.
- Abstract
Summary:This randomised trial was designed to compare two groups treated with different G-CSF administration schedules with a third group receiving no G-CSF, after autologous peripheral blood stem cell transplantation (APBSCT). Children and adults with haematological malignancies or solid tumours were randomly assigned to receive either 150 μg/m2/day of Lenograstim starting on day 1 (G1) or on day 5 (G5) post APBSCT, or no Lenograstim (G0). Randomisation was stratified according to the conditioning regimen (Busulfan vs TBI vs no Busulfan and no TBI) and the graft CD 34+ cell count. A total of 240 patients were randomised; 239 were evaluable. All three patient groups were comparable. Median duration of neutropenia was 9 days (4–40), and 10 days (5–15) in the G1 and G5 groups, respectively, significantly shorter than in the G0 group, 13 days (7–36) (P<0.0001). No difference was observed in the duration of thrombocytopenia, transfusion support and extra-haematological complications. The duration of post transplant hospitalisation was significantly shorter in adults who received G-CSF. Clinical and cost arguments favour the initiation of G-CSF on day 5 in adults. The same policy could be applied in children given that clinical management is easier and costs are similar.Bone Marrow Transplantation (2005) 36, 547–552. doi:10.1038/sj.bmt.1705097; published online 11 July 2005
- Subjects
STEM cell transplantation; COST effectiveness; BONE marrow transplantation; BLOOD diseases; COST analysis; HEMATOLOGY
- Publication
Bone Marrow Transplantation, 2005, Vol 36, Issue 6, p547
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705097