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- Title
Comparisons of Metaphylactic Treatments of Zactran® (gamithromycin) vs. Excede® (ceftiofur crystalline free acid) in High Risk, Stocker Calves.
- Authors
Amrine, David; White, Brad; Goehl, Dan; Sweiger, Shaun H.; Nosky, Bruce; Tessman, Ronald K.
- Abstract
Bovine respiratory disease (BRD) complex is the most common disease occurring in backgrounding and feedlot cattle and is a significant source of losses from poor performance and death. Metaphylactic treatments are recognized as economically advantageous and have been associated with a 50% reduction in BRD associated morbidity. The multi-site study described here was conducted to compare health and performance parameters between newly received stocker calves treated metaphylactically with Zactran® (6 mg gamithromycin/kg subcutaneously) compared to Excede® (6.6 mg ceftiofur/kg subcutaneously). Cattle (N = 1853) were beef or beef cross bulls, steers, and heifers approximately 4 to 11 months old of auction market origin. At a single study site in Oklahoma, calves (n = 1045) weighing between 115 to 258 kg (254-568 lb) were received over a period of two months. Five sites in northeast Missouri enrolled calves (n=808) weighing between 179 to 322 kg (395-710 lb) over a period of five months. Calves were randomized to treatment at each site and were penned according to treatment. Blinded personnel monitored calves daily for clinical signs of illness and up to three sequential administrations of BRD therapy with approved antimicrobials were given to animals with a clinical illness score (CIS) > 1 and a rectal temperature >40°C (104.0°F) or with a CIS > 2. Calves metaphylactically treated for BRD with Zactran® gained significantly more weight (28.51 ± 6.14 kg vs. 24.46 ± 6.14 kg; p<0.05) than calves treated with Excede®. Fewer first pulls were required for calves treated with Zactran® (probability: 0.32 ± 0.07 vs. 0.38 ± 0.08; p<0.01) compared to calves treated with Excede®.
- Subjects
TREATMENT of cattle diseases; BOVINE respiratory syncytial virus diseases
- Publication
International Journal of Applied Research in Veterinary Medicine, 2014, Vol 12, Issue 3, p221
- ISSN
1559-4602
- Publication type
Article