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- Title
EVALUAREA ÎMBĂTRÂNIRII ŞI ATEROSCLEROZEI PRIN MARKERI SERICI DE LIPOPEROXIDARE.
- Authors
Zorilă, Corina; Moş, Liana; Şuşan, Lelia
- Abstract
Aim. Oxidative attack of oxygen free radicals on fatty acids of cell membranes, called lipoperoxidation, is one of the well-known mechanisms associated with aging. We have studied the involvement of lipoperoxidation by determining malondialdehyde as thiobarbituric acid (ATB) -reactive substances in peripheral venous blood. Material and method. We evaluated a group of 33 elderly with cardiovascular disease and/or hypertension (lot I) of atherosclerotic etiology. Patients were hospitalized for decompensated cardiovascular diseases, mainly for symptomatic ischemic heart disease, stable angina, aggravated angina pectoris, left ventricular failure, peripheral arterial disease. We compared this group with another group of patients without symptomatic ischemic heart disease (clinical and ECG), in which we determined the extension of lipoperoxidation, as ATB-reactive substances under basal conditions and in terms of hemodynamic balance (Satoh method). Results. In the study we found the extension lipoperoxidation elevated as ATB reactive substances in the group of patients with vascular disease aged over 60 years, compared with the control group. The average of the ATB reactive substances was 4.54 +/- 0.62 μmol/l vs 2.69 +/- 0.54 μmol/l (p <0.001). Conclusions. The data found in this study come to support the involvement of oxygen free radicals in aging, by extension of non-enzymatic lipoperoxidation process, without being able to determine whether oxidative stress is a cause or consequence of aging.
- Publication
Internal Medicine / Medicină Internă, 2015, Vol 12, Issue 6, p29
- ISSN
1220-5818
- Publication type
Article