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- Title
The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care.
- Authors
Trybula, S. Joy; Youngblood, Mark W.; Karras, Constantine L.; Murthy, Nikhil K.; Heimberger, Amy B.; Lukas, Rimas V.; Sachdev, Sean; Kalapurakal, John A.; Chandler, James P.; Brat, Daniel J.; Horbinski, Craig M.; Magill, Stephen T.
- Abstract
Simple Summary: Meningiomas are the most common intracranial tumors, and significant advances have been made in our understanding of the biology that leads to meningioma growth and aggressiveness. This review summarizes molecular advances and the historical contexts that led to them. Meningioma classification and treatment have evolved over the past eight decades. Since Bailey, Cushing, and Eisenhart's description of meningiomas in the 1920s and 1930s, there have been continual advances in clinical stratification by histopathology, radiography and, most recently, molecular profiling, to improve prognostication and predict response to therapy. Precise and accurate classification is essential to optimizing management for patients with meningioma, which involves surveillance imaging, surgery, primary or adjuvant radiotherapy, and consideration for clinical trials. Currently, the World Health Organization (WHO) grade, extent of resection (EOR), and patient characteristics are used to guide management. While these have demonstrated reliability, a substantial number of seemingly benign lesions recur, suggesting opportunities for improvement of risk stratification. Furthermore, the role of adjuvant radiotherapy for grade 1 and 2 meningioma remains controversial. Over the last decade, numerous studies investigating the molecular drivers of clinical aggressiveness have been reported, with the identification of molecular markers that carry clinical implications as well as biomarkers of radiotherapy response. Here, we review the historical context of current practices, highlight recent molecular discoveries, and discuss the challenges of translating these findings into clinical practice.
- Subjects
METHYLATION; WORLD Health Organization; EPIGENOMICS; RADIOMICS; PATIENT care; TUMOR grading; POSITRON emission tomography; GENE expression; MENINGIOMA; GENETIC mutation; MOLECULAR diagnosis
- Publication
Cancers, 2024, Vol 16, Issue 9, p1753
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16091753