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- Title
One-Year Follow-Up after Multimodal Prehabilitation Interventions in Radical Cystectomy.
- Authors
Thoft Jensen, Bente; Bjerggaard Jensen, Jørgen
- Abstract
Simple Summary: This study group has previously published and documented that multimodal prehabilitation (enhanced optimization of physical function and adjustment of modifiable medical issues) before major bladder surgery is feasible and leads to a positive change in patients' fitness and functional status from a short-term perspective after surgery. However, long-term follow-ups after prehabilitation have not yet been published. Thus, this study aims to evaluate 1-year results on the efficacy of physical prehabilitation on functional capacity and nutritional recovery to inform the bladder cancer community of the potential of prehabilitation. The results show that prehabilitation in major bladder cancer surgery can significantly improve physical function and support the maintenance of nutritional status one year after major bladder cancer surgery. The results promote the gradual recognition that early restoration of physical function is vital to a full recovery. Multimodal prehabilitation is the process of enhancing physiological, nutritional, and psychological resilience to increase patients' functional capacity before major cancer surgery and aims to empower the patient to withstand the pending stress of major surgery and ultimately to improve long-term outcomes. The effect of physical prehabilitation to counteract the physical decline in surgical cancer patients has been documented; however, long-term results have not yet been published. This follow-up study aims to evaluate 1-year results on the efficacy of physical prehabilitation after bladder cancer surgery. The efficacy of prehabilitation was measured over the course of 1 year in 107 patients randomized to (1) pre- and rehabilitation or (2) standard care divided by n = 50 in the intervention (I) and n = 57 in the standard group (S). Physical function was measured by muscle leg power, and nutritional status was expressed with handgrip strength. Prehabilitation in major bladder cancer surgery can significantly improve physical function with 19.8 Watt/kg (p = 0.04), lean body mass (p = 0.047) and body cell mass (p = 0.03), and regained nutritional status one year after surgery. The results demonstrate that the restoration of physical function is vital to a full recovery.
- Subjects
BLADDER tumors; CYSTECTOMY; STATISTICS; CONFIDENCE intervals; PHYSICAL therapy; FUNCTIONAL status; CONVALESCENCE; MANN Whitney U Test; RANDOMIZED controlled trials; CANCER; PEARSON correlation (Statistics); T-test (Statistics); DESCRIPTIVE statistics; CHI-squared test; REHABILITATION; PREHABILITATION; DATA analysis software; DATA analysis; NUTRITIONAL status
- Publication
Cancers, 2023, Vol 15, Issue 24, p5785
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers15245785