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- Title
Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blind Placebo-Controlled Trial.
- Authors
Abedi, Sara; Taebi, Mahboubeh; Esfahani, Mohammad Hosein Nasr
- Abstract
Background: Despite numerous studies indicating an imperative role for reproduction, however, the role of Vitamin D supplementation on outcomes of assisted reproductive techniques remains controversial. This clinical trial was performed to evaluate the effect of Vitamin D supplementation 6 weeks prior to intracytoplasmic sperm injection (ICSI) on fertility indices. Materials and Methods: The present study was a double-blind clinical trial conducted on infertile women was randomly allocated into two groups: Vitamin D supplementation (42 participants) and placebo (43 participants). Serum Vitamin D was measured before and six to eight weeks after treatment, on the day of ovum pick up. Results were analyzed using SPSS16 and fertility indices were compared between the two groups. Results: No significant difference was observed between the intervention and control groups regarding the mean number of oocytes retrieved, percentage mature oocyte, fertilization rate and the rate of good quality embryos (all P>0.05). But, percentages of the individual with suitable endometrium (7-14 mm thickness) were significantly higher in the Vitamin D compared to control group (P=0.011). The rate of chemical (47.6 vs. 25.5%, P=0.013) and clinical pregnancy rate (38.1 vs. 20.9%, P=0.019) were also significantly higher in the Vitamin D compared to control group. Conclusion: The present study reveals that consuming Vitamin D for 6 weeks prior to ICSI improves quality of endometrium, rate of chemical and clinical pregnancy (Registration Number: IRCT2015111124999N1).
- Subjects
ENDOMETRIUM physiology; OVUM analysis; DIETARY supplements; FERTILITY; FERTILIZATION in vitro; EVALUATION of medical care; PREGNANCY; TIME; VITAMIN D; RANDOMIZED controlled trials; BLIND experiment; DATA analysis software
- Publication
International Journal of Fertility & Sterility, 2019, Vol 13, Issue 1, p18
- ISSN
2008-076X
- Publication type
Article
- DOI
10.22074/ijfs.2019.5470