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- Title
Comparison and Optimization of Different Methods for the In Vitro Production of Plasmodium falciparum Gametocytes.
- Authors
Roncalés, María; Vidal-Mas, Jaume; Leroy, Didier; Herreros, Esperanza
- Abstract
The generation of sexually committed parasites (gametocytogenesis) is poorly understood in malaria. If themechanisms regulating this process were elucidated, new opportunities for blocking malaria transmission could be revealed. Here we compare several methods described previously for the in vitro production of Plasmodium falciparum gametocytes. Our approach relies on the combination of several factors that we demonstrated as impacting on or being critical to gametocytogenesis. An improved method has been developed for the in vitro production of P. falciparum gametocytes as the first step toward obtaining adequate numbers of pure gametocytes for in vitro studies, such as, for example, the identification of transmission blocking drugs.
- Subjects
PLASMODIUM falciparum; FERTILIZATION in vitro; GERM cells; MALARIA transmission; COMPARATIVE studies
- Publication
Journal of Parasitology Research, 2012, p1
- ISSN
2090-0023
- Publication type
Article
- DOI
10.1155/2012/927148