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- Title
Transcription Factor AP-2β Genotype Associated with Anxiety-Related Personality Traits in Women.
- Authors
Berggård, Cecilia; Mattila-Evenden, Marja; Rylander, Gunnar; Forslund, Kaj; Garpenstrand, Håkan; Bergman, Hans; Gustavsson, J. Petter; Jönsson, Erik G.; Damberg, Mattias
- Abstract
Attempts to link transmitter system genes to certain aspects of personality have been performed. Several monoamine-related gene variants have been investigated. We previously reported an association between a transcription factor activating protein-2β (AP-2β) variant and anxiety-related personality traits as estimated by Karolinska Scales of Personality (KSP). To confirm this reported association, we have, in the present study, analysed an enlarged group of healthy volunteers (n = 370) with regard to AP-2β genotype and personality traits. For estimation of personality traits, individuals completed 5 different personality questionnaires, i.e. Swedish Universities Scales of Personality (SSP), Health-Relevant 5- Factor Personality Inventory (HP5i), Temperament and Character Inventory, the Revised NEO Personality Inventory and KSP. In contrast to men, women having two long AP-2β alleles displayed lower scores for muscular tension (KSP; F = 10.65, p = 0.0013), somatic trait anxiety (SSP; F = 7.18, p = 0.0081), trait irritability (SSP; F = 4.51, p = 0.032), mistrust (SSP; F = 4.01, p = 0.0468) and negative affectivity (HP5i; F = 10.20, p = 0.0017) than women with at least one short allele. The data presented in this study, together with our previously published data, suggest that AP-2β intron 2 genotype is associated with low levels of anxiety-related personality traits in women. Hence, these data further suggest the human AP-2β gene as a novel candidate gene in personality. Copyright © 2003 S. Karger AG, Basel
- Subjects
TRANSCRIPTION factors; PERSONALITY; GENETIC research; ANXIETY; DEPRESSION in women; INVENTORIES
- Publication
Neuropsychobiology, 2003, Vol 48, Issue 4, p169
- ISSN
0302-282X
- Publication type
Article