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- Title
The Impact of Letrozole Versus Clomiphene Citrate on Uterine Blood Flow in Patients with Unexplained Infertility.
- Authors
Sakhavar, Nahid; Kaveh, Mania; Sadegi, Kambiz
- Abstract
Objective: To compare the effectiveness of letrozole and clomiphene citrate (CC) on uterine blood flow rate in patients with unexplained infertility. Materials and methods: In this randomized clinical trial 90 women with unexplained infertility referred to a university clinic from January 2011- December 2013 were enrolled. Thirty patients were randomized for letrozole, 30 patients for CC and 3o patients for control group. On the day 3 of cycle the patients were given letrozole 2.5mg/day or CC 100 mg /day orally or did not receive any treatment. Resistance index (RI) and pulsatility index (PI) of uterine artery were calculated and chemical pregnancy rate was evaluated. Results: Mean age was 26.4±3.2 (20-33) and mean BMI was 26.3± 3.2. After treatment using ultrasonography the Resistance index (RI) and Pulsatility index (PI) showed no significant difference among three groups (P>0.05). Pregnancy rate in letrozole group (58%) was more in comparison to CC (53.6%) and control groups (46%) but the difference was not significant (P>0.05). Conclusion: Our study showed that letrozole and clomiphene citrate have comparable impact on uterine blood flow and pregnancy rate in women with unexplained infertility.
- Subjects
LETROZOLE; CLOMIPHENE; BLOOD flow measurement; INFERTILITY; RANDOMIZED controlled trials; UTERINE artery; FEMALE infertility; PATIENTS; THERAPEUTICS
- Publication
Journal of Family & Reproductive Health, 2014, Vol 8, Issue 1, p1
- ISSN
1735-8949
- Publication type
Article