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- Title
HIV-negative Kaposi sarcoma manifesting as foot lesion in a patient with diabetes mellitus: a case study.
- Authors
Khan, Farishta; Millette, Dijon; Siddique, Roshan; Siddique, Haroon
- Abstract
Kaposi's sarcoma caused by Kaposi's sarcoma-associated virus, is a rare malignancy in the general population with unique features. However, clinical presentation on the feet can mimic a diabetic foot ulcer. Here we describe the case of a 63-year-old male with type 2 diabetes, who presented with a lesion on the left 4th toe. Left foot radiograph in lateral and dorsoplantar views were normal. Full skin examination identified lesions with a similar morphology on the forearms. A HIV antigen/antibody test was negative, histology showed CD31 positive spindle cells and the presence of Kaposi's sarcoma-associated virus confirming the diagnosis of Kaposi's sarcoma. Kaposi's sarcoma-associated virus' lytic cycle can be triggered by the immunosuppressive state caused by tissue's chronic exposure to a hyperglycaemic environment. A thorough general examination to identify lesions elsewhere in the body can help to identify the systemic nature of the disease. Pedal lesions in patients with diabetes with an atypical presentation that are refractory to standard treatment should prompt early histological examination. Early diagnosis and intervention can improve the chances of remission.
- Subjects
PHYSICAL diagnosis; ENDOTHELIAL cells; BIOMARKERS; DELAYED diagnosis; DIABETIC foot; IMMUNOHISTOCHEMISTRY; GLYCEMIC control; CUTANEOUS manifestations of general diseases; DIFFERENTIAL diagnosis; TOE joint; SOCIAL stigma; KAPOSI'S sarcoma; TYPE 2 diabetes; AIDS serodiagnosis; CELL adhesion molecules; CELLS; RADIATION doses; EARLY diagnosis; EARLY medical intervention
- Publication
Wounds UK, 2024, Vol 20, Issue 1, p9
- ISSN
1746-6814
- Publication type
Article