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- Title
Effects of metformin and insulin on gestational diabetes mellitus: A dual drugs therapy approach.
- Authors
Yalou Jiao; Zhe Qiao; Ruiying Han; Jie Du; Jian Zhang; Sheng Zhang
- Abstract
This study was aimed to investigate the combined effects of metformin hydrochloride and insulin during gestational diabetes mellitus. A total 136 patients were randomly divided into study and control group. The control group was treated with insulin only while the study group was additionally treated with metformin hydrochloride. Maternalinfant outcomes and the levels of fasting blood glucose (FBG), 2h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), total bilirubin (TBil), uric acid (UA) and microalbunminuria (mAlb) before and after treatment were compared. In post-treatment, the levels of FBG, 2h PG and HbA1c were decreased significantly (p<0.05) in both groups compared with pre-treatment. The levels of TC, TBil, UA and mAlb in both groups were significantly improved compared with pre-treatment. Levels of TC, UA and mAlb in the study group were significantly lower while TBil level was higher than control group. Compared to the control group, the incidence of gestational hypertension and premature delivery were significantly lower in the study group. There was no significant difference in the incidence of neonatal respiratory distress. The combination of metformin hydrochloride and insulin has significant effect in the treatment of gestational diabetes mellitus.
- Subjects
GESTATIONAL diabetes; DRUG therapy; INSULIN; METFORMIN; GLYCOSYLATED hemoglobin
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 1, p161
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2022.35.1.REG.161-164.1