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- Title
Adhesion molecules in renal disease.
- Authors
Dal Canton, Antonio
- Abstract
The article discusses the pathophysiological role of adhesion molecules in renal disease. Anti-Fx1A antibodies inhibited the adhesion of glomerular visceral epithelial cells (GEC) to several substra. This suggests that the binding of such antibodies to the main integrin receptor of podocytes may change the normal adhesion of GEC to glomerular basement membrane. This leads to cell detachment which is responsible for altered glomerular permeability and proteinuria.
- Subjects
CELL adhesion molecules; PROTEINURIA; KIDNEY diseases; IMMUNOGLOBULINS; PATHOLOGICAL physiology
- Publication
Kidney International, 1995, Vol 48, Issue 6, p1687
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1995.466