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- Title
Tissue distribution of thiopental and diazepam in rats at 71 atmospheres pressure.
- Authors
Aanderud, L; Thoner, J; Bakke, O M
- Abstract
35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.
- Publication
Acta Anaesthesiologica Scandinavica, 1983, Vol 27, Issue 6, p433
- ISSN
0001-5172
- Publication type
journal article