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- Title
ANO1: an additional key player in cyst growth.
- Authors
Tanaka, Tetsuhiro; Nangaku, Masaomi
- Abstract
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an embryonic kidney cyst model. Their results support a potential role for this chloride channel in cyst generation.
- Subjects
CHLORIDE cells; CALCIUM acetate; KIDNEY abnormalities; COLLAGEN genetics; KIDNEY tumors; BIOLOGICAL transport; PROGNOSIS; DIAGNOSIS
- Publication
Kidney International, 2014, Vol 85, Issue 5, p1007
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2013.436