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- Title
Early-onset type 2 diabetes: higher burden of atherogenic apolipoprotein particles during statin treatment.
- Authors
Song, S.H.; Gray, T.A.
- Abstract
Aims: To determine the burden of atherogenic apolipoprotein particles in early-onset type 2 diabetes (T2D) compared to those with later-onset disease during statin treatment.Methods: Early and later-onset T2D was defined as current age below and above 40 years respectively. Conventional lipid profile, LDL, non-HDL cholesterol, apolipoprotein B and A1 were determined in those without cardiovascular disease treated with simvastatin to achieve LDL cholesterol <2 mmol/l.Results: Fifty subjects were recruited (early-onset n = 24 and later-onset n = 26). The mean age was 34.5 and 59.6 years and mean age of diagnosis was 29.1 and 49.1 years for early and later-onset T2D respectively. Obesity, dyslipidaemia, microalbuminuria, glycaemic control and diabetes complication burden were similar in both cohorts. Early-onset subjects received non-significantly higher simvastatin dose (37.5 vs. 31.9 mg daily, p = NS). On-treatment LDL cholesterol was similar in both cohorts (early vs. later-onset; 2.12 vs. 1.97 mmol/l, p = NS). Fasting triglyceride, non-HDL, apo B and B/A1 ratio were significantly higher in early-onset cohort. There was no difference in apo A1, HDL and total cholesterol/HDL ratio. Apo B level remained significantly higher among early-onset subjects after adjustment for insulin treatment. Lower current age and age of diagnosis were significant predictors of higher apo B level.Conclusions: The burden of atherogenic apolipoprotein particles was greater in early-onset T2D despite adequate statin treatment indicating an adverse phenotype for vascular disease.
- Subjects
TYPE 2 diabetes treatment; APOLIPOPROTEIN B; STATINS (Cardiovascular agents); HIGH density lipoproteins; PARTICLES; COMPARATIVE studies; HUMAN phenotype
- Publication
QJM: An International Journal of Medicine, 2012, Vol 105, Issue 10, p973
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcs113