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- Title
Increased cyclooxygenase-2, hyperfiltration, glomerulosclerosis, and diabetic nephropathy: put the blame on the (pro)renin receptor?
- Authors
Nguyen, G.
- Abstract
Interaction between the renin-angiotensin system and cyclooxygenases in the kidney regulates renal microcirculation. Activation of the (pro)renin receptor has profibrotic effects, and now Kaneshiroet al. show that it also increases COX-2 synthesis. These results may have therapeutic implications, as blocking (pro)renin-receptor interaction would prevent the increase of angiotensin generation and prostaglandin synthesis, two phenomena underlying the pathogenesis of diabetic nephropathy.Kidney International (2006) 70, 618–620. doi:10.1038/sj.ki.5001723
- Subjects
CYCLOOXYGENASE 2; DIABETIC nephropathies; RENIN; MICROCIRCULATION; ANGIOTENSINS; PROSTAGLANDINS
- Publication
Kidney International, 2006, Vol 70, Issue 4, p618
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5001723