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- Title
Identification of a Pathway from the Retina to Koniocellular Layer K1 in the Lateral Geniculate Nucleus of Marmoset.
- Authors
Percival, Kumiko A.; Koizumi, Amane; Masri, Rania A.; Buzás, Péter; Martin, Paul R.; Grünert, Ulrike
- Abstract
Three well characterized pathways in primate vision (midget-parvocellular, parasol-magnocellular, bistratified-koniocellular) have been traced from the first synapse in the retina, through the visual thalamus (lateral geniculate nucleus, LGN), to the visual cortex. Here we identify a pathway from the first synapse in the retina to koniocellular layer K1 in marmoset monkeys (Callithrix jacchus). Particlemediated gene transfer of an expression plasmid for the postsynaptic density 95-green fluorescent protein (PSD95-GFP) was used to label excitatory synapses on retinal ganglion cells and combined with immunofluorescence to identify the presynaptic bipolar cells. We found that axon terminals of one type of diffuse bipolar cell (DB6) provide dominant synaptic input to the dendrites of narrow thorny ganglion cells. Retrograde tracer injections into the LGN and photofilling of retinal ganglion cells showed that narrow thorny cells were preferentially labeled when koniocellular layer K1 was targeted. Layer K1 contains cells with high sensitivity for rapid movement, and layer K1 sends projections to association visual areas as well as to primary visual cortex. We hypothesize that the DB6-narrow thorny-koniocellular pathway contributes to residual visual functions (“blindsight”) that survive injury to primary visual cortex in adult or early life.
- Subjects
RETINA; GENICULATE bodies; MARMOSETS as laboratory animals; VISUAL cortex; GENETIC transformation; GREEN fluorescent protein; RETINAL ganglion cells; IMMUNOFLUORESCENCE
- Publication
Journal of Neuroscience, 2014, Vol 34, Issue 11, p3821
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4491-13.2014