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- Title
Is homocysteine an iron-dependent cardiovascular risk factor?
- Authors
Sullivan, J. L.
- Abstract
Recent studies of endothelial function suggest that adverse vascular effects of homocysteine are iron-dependent. Iron sucrose worsens and iron chelation eliminates homocysteine-associated decreases in flow-mediated dialation. There may be no vasculopathic effect of homocysteine without available reactive iron. Iron-dependent amplification of the vascular effects of homocysteine may be one of several mechanisms by which stored iron increases cardiac risk.Kidney International (2006) 69, 642–644. doi:10.1038/sj.ki.5000229
- Subjects
HOMOCYSTEINE; DISEASE risk factors; CARDIAC arrest; HEART diseases; IRON; SUCROSE; GLUCOSE
- Publication
Kidney International, 2006, Vol 69, Issue 4, p642
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/sj.ki.5000229