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- Title
Synthesis and Antibacterial Activity of 2-(2,4- Dinitrophenyl)-3,5- diphenyl (substituted)-6-aryl- 3,3a,5,6-tetrahydro tetrahydro--2H-pyrazolo[3,4- d] thiazoles.
- Authors
Sahu, S. K.; Mishra, S. K.; Mohanta, R. K.; Pattanayak, S. P.; Panda, C. S.
- Abstract
Condensation of substituted benzaldehydes with primary aryl amines gave a series of Schiff bases(1a1-e1,a2,b2,d2,b3-e3) which, on reaction with thioglycolic acid, resulted in the formation of the corresponding 4-thiazolidinones (2a1-e1,a2,b2,d2,b3-e3). These compounds, on condensation with substituted benzaldehydes in anhydrous sodium acetate, furnished 2-phenyl(substituted)-3-aryl-5-benzilidine(substituted)-thiazolidine-4-ones (3a1-e1,a2,b2,d2,b3-e3). The latter, on heating with 2,4-dinitrophenyl hydrazine in anhydrous sodium acetate, gave the title compounds(4a1-e1,a2,b2,d2,b3-e3). The structures have been established on the basis of elemental analysis and spectral data. The title compounds have been screened in vitro for their possible antibacterial activity.
- Subjects
THIAZOLES; BENZALDEHYDE; DISINFECTION &; disinfectants; HYDRAZINE; AROMATIC amines; CONDENSATION
- Publication
Indian Journal of Pharmaceutical Sciences, 2006, Vol 68, Issue 3, p377
- ISSN
0250-474X
- Publication type
Article
- DOI
10.4103/0250-474X.26686