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- Title
Poikiloderma Vasculare Atrophicans: A Distinct Clinical Entity?
- Authors
Mahajan, Vikram K.; Chauhan, Pushpinder S.; Mehta, Karaninder S.; Sharma, Anju Lath
- Abstract
This paper describes a typical case of poikiloderma vasculare atrophicans (PVA) in a 48‑year‑old female. Histologically, the features were suggestive of PVA with the absence of Pautrier's microabscess or atypical lymphoid cells. The biopsy specimen was positive for cluster of differentiation (CD) 8 on immunohistochemical staining. Its exact pathogenesis remains obscure, and it remains unclear whether PVA actually is mycosis fungoides (MF), a forme fruste of MF, or a distinct and benign dermatosis with CD8+ phenotype that can perhaps be labeled as PVA. However, it has a long benign clinical course without progression to tumor stage of MF in most cases, and its status within the spectrum of cutaneous T‑cell lymphoma remains poorly understood. Yet it is imperative to distinguish PVA from poikilodermic MF.
- Subjects
ROTHMUND-Thomson syndrome; COLLAGEN diseases; DIFFERENTIAL diagnosis; HISTOLOGY; DIAGNOSIS
- Publication
Indian Journal of Dermatology, 2015, Vol 60, Issue 2, p1
- ISSN
0019-5154
- Publication type
Article
- DOI
10.4103/0019-5154.152566