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- Title
Therapeutic Round. Delivery of Amphotericin B for Effective Treatment of Candida albicans Induced Dermal Mycosis in Rats via Emulgel System: Formulation and Evaluation.
- Authors
Ganeshpurkar, Aditya; Vaishya, Pooja; Jain, Sumeet; Pandey, Vikas; Bansal, Divya; Dubey, Nazneen
- Abstract
Background: Amphotericin B (AmB) is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. However, the drug has various side- effects. Transdermal approach for the delivery of drug is one of the accepted and convenient modes of drug delivery. Aim: The current work was designed to formulate and to evaluate the AmB emulgel system. Materials and Methods: In the preparation of AmB emulgel, Carbopol 930 was used as a gel in this study. The formulation was evaluated for viscosity, spreadability, drug content, drug release and in vitro and in vivo antifungal testing. Results: AmB emulgel was found to penetrate skin effectively and without any irritation. Further, in vivo studies revealed effective therapeutic potential against Candida albicans induced dermal mycosis. Conclusions: The current work, for the first time, revealed effective delivery of AmB across the skin.
- Subjects
CANDIDIASIS treatment; SKIN disease diagnosis; ACID-base equilibrium; AMPHOTERICIN B; ANIMAL experimentation; BIOLOGICAL assay; BIOPHYSICS; CENTRIFUGATION; DERMATOLOGY; DRUG administration; DRUG prescribing; RESEARCH methodology; MICROBIOLOGY; MYCOSES; PERMEABILITY; RATS; SERIAL publications; TRANSDERMAL medication; PHYSICIAN practice patterns; IN vitro studies
- Publication
Indian Journal of Dermatology, 2014, Vol 59, Issue 4, p369
- ISSN
0019-5154
- Publication type
Article
- DOI
10.4103/0019-5154.135489