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- Title
HIV-1 persistence in CD4<sup>+</sup> T cells with stem cell-like properties.
- Authors
Buzon, Maria J; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J; Li, Jonathan Z; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D; Rosenberg, Eric S; Yu, Xu G; Lichterfeld, Mathias
- Abstract
Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM cells) harbor high per-cell levels of HIV-1 DNA and make increasing contributions to the total viral CD4+ T cell reservoir over time. Moreover, we conducted phylogenetic studies that suggested long-term persistence of viral quasispecies in CD4+ TSCM cells. Thus, HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence.
- Subjects
THERAPEUTICS; HIV infections; ANTIRETROVIRAL agents; CELLULAR immunity; T cells; STEM cells; DNA
- Publication
Nature Medicine, 2014, Vol 20, Issue 2, p139
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm.3445