We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunological Unresponsiveness to Protein Antigens in Rabbits Exposed to X-Irradiation or 6-Mercaptopurine Treatment.
- Authors
Nachtigal, D.; Feldman, M.
- Abstract
Immune unresponsiveness to Has and BSA was induced in adult rabbits exposed to 550 R. total-body irradiation. Immunogenic doses of antigen, 20-75 mg., were found to be tolerogenic in this system. The degree of unresponsiveness was found to be a function of the time interval between X-irradiation and the beginning of antigen administration. The unresponsive animals retained the circulating antigen in quantities detectable by the gel-diffusion technique. These results were compared with the state of unresponsiveness induced by means of 6-mercaptopurine, and similar parameters were found to be operative. Some aspects of the significance of the ratio of antigen to competent cells, in the induction' of immune unresponsiveness, are discussed.
- Subjects
IMMUNE response; ANTIGENS; PHYSIOLOGICAL effects of radiation; RABBITS; THIOLS; IMMUNOLOGY
- Publication
Immunology, 1963, Vol 6, Issue 4, p356
- ISSN
0019-2805
- Publication type
Article