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- Title
Hearing loss with phosphodiesterase-5 inhibitors.
- Authors
Thakur, Jagdeep S.; Thakur, Somesh; Sharma, Dev R.; Mohindroo, Narinder K.; Thakur, Anamika; Negi, Prakash C.
- Abstract
Objectives/Hypothesis To assess the effect of tadalafil on auditory functions. Study Design Prospective observational study in a tertiary care hospital. Methods Twenty-five tadalafil naïve patients with erectile dysfunction or pulmonary artery hypertension were subjected to pure-tone and brainstem-evoked response audiometry before drug therapy, and 3 and 30 days following drug therapy. Results were compared using analysis of variance for repeated measures with Bonferonni correction. Results Fifteen patients were taking tadalafil 10 mg for erectile dysfunction, and another 10 patients were on tadalafil 20 mg once daily for pulmonary artery hypertension. No statistically significant difference was found in hearing threshold at baseline and at follow-up ( P > .05). However, three patients on tadalafil 20 mg showed a significant increase in hearing threshold at higher frequencies. There was no incidence of sudden sensorineural hearing loss in the study group. Conclusions This is the first prospective and observational study that evaluated the effect of tadalafil on auditory functions with objective tests. Although there was no statistically significant result to confirm or refute the association between tadalafil and hearing impairment, increased threshold at higher frequencies after taking tadalafil supports the results from previous studies and hints at a possible relationship between the two. Similar large sample studies are warranted to know the exact association of phosphodiesterase-5 inhibitors on auditory functions. Level of Evidence 4.
- Subjects
TREATMENT of deafness; DRUG therapy; TADALAFIL; PHOSPHODIESTERASE inhibitors; AUDITORY evoked response; IMPOTENCE
- Publication
Laryngoscope, 2013, Vol 123, Issue 6, p1527
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.23865