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- Title
Organization of secondary lymphoid tissue and local IgE formation toStaphylococcus aureusenterotoxins in nasal polyp tissue.
- Authors
Gevaert, P.; Holtappels, G.; Johansson, S. G. O.; Cuvelier, C.; Van Cauwenberge, P.; Bachert, C.
- Abstract
Bilateral nasal polyposis (NP) is characterized by high concentrations of IgE in NP tissue, which show no relation to the atopic status. We aimed to study the relationship between systemic and local IgE formation, nasal carriage ofStaphylococcus aureusand nasal polyposis.In serum and nasal tissue homogenates from 24 NP patients and 12 controls, we determined concentrations of total IgE and IgE antibodies to inhalant allergens andS. aureusenterotoxins (SAEs; A,B,C,D,E,TSST) by ImmunoCAP. Tissue cryosections were stained for CD3, CD20, CD38, CD23, FcεRI, IgE and SEA/SEB.We demonstrated a higher incidence ofS. aureuscolonization (17/24) and IgE antibodies to SAEs in NP tissue (12/24) compared with controls (3/12 and 0/12, respectively). Total IgE and IgE antibodies in serum and NP tissue were dissociated because of local polyclonal IgE formation in NP tissue. Staining of NP tissue revealed follicular structures characterized by B and T cells, and lymphoid accumulations with diffuse plasma cell infiltration.We demonstrated the organization of secondary lymphoid tissue in polyp tissue and a polyclonal hyper-immunoglobulinemia E associated with the presence of IgE antibodies to SAEs, colonization withS. aureus, and tissue eosinophilia in a relevant subgroup of polyp patients.
- Subjects
NASAL polyps; BIOMARKERS; IMMUNOGLOBULIN E; STAPHYLOCOCCUS aureus; ANTI-immunoglobulin E autoantibodies; ALLERGIES; LYMPHOID tissue
- Publication
Allergy, 2005, Vol 60, Issue 1, p71
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/j.1398-9995.2004.00621.x