We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clostridioides difficile Flagella.
- Authors
Marvaud, Jean-Christophe; Bouttier, Sylvie; Saunier, Johanna; Kansau, Imad
- Abstract
Clostridioides difficile is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors. But the dysbiosis of the intestinal microbiota creating the conditions for the colonization appears to be fundamental for our understanding of the disease. Colonization implies several steps for the bacteria that do or do not use their capacity of motility with the synthesis of flagella. In this review, we focus on the current understanding of different topics on the C. difficile flagellum, ranging from its genetic organization to the vaccinal interest in it.
- Subjects
FLAGELLA (Microbiology); NOSOCOMIAL infections; BACTERIAL toxins; GUT microbiome; DYSBIOSIS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 4, p2202
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25042202