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- Title
Mediterranean-style dietary pattern is associated with surrogate measures of insulin resistance in the Framingham Offspring Cohort.
- Authors
Rumawas, Marcella E.; McKeown, Nicola M.; Rogers, Gail; Dwyer, Johanna T.; Meigs, James M.; Jacques, Paul F.
- Abstract
The traditional Mediterranean diet is associated with a lower risk of cardiovascular diseases (CVD). Improved insulin sensitivity may be one mechanism by which adoption of Mediterranean-style dietary pattern may reduce CVD risk. A diet score was developed to capture a Mediterranean-style dietary pattern in the Framingham Offspring Cohort. We examined the relationship between this diet score and insulin resistance markers (fasting & 2-hr plasma glucose & insulin and the homeostasis model assessment insulin resistance [HOMA-IR]) in 1238 men & 1505 women without diabetes in the cohort. After adjustment for potential confounding factors, a higher diet score, reflecting greater similarity to Mediterranean-style dietary pattern, was associated with lower fasting insulin levels (mean 35 vs 32 µU/mL in the lowest vs highest quartiles of diet score; P trend<0.01), 2-hr insulin (116 vs 98 µU/mL; P trend<0.01), HOMA-IR (8.4 vs 7.7; P trend<0.01) in subjects with abdominal obesity (waist circumference >108 cm in men or >88 cm in women), but not in those with lesser waist circumferences. No significant association was found between the Mediterranean diet score and fasting and 2-hr glucose. In individuals with greater abdominal adiposity, greater consistency with a Mediterranean-style dietary pattern was associated with better insulin sensitivity.
- Subjects
DIET; INSULIN resistance; INSULIN; GLUCOSE; ABDOMEN; OBESITY
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA6
- ISSN
0892-6638
- Publication type
Article