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- Title
Granzyme B mediates neurotoxicity through a G-protein-coupled receptor.
- Authors
Tongguang Wang; Allie, Rameeza; Conant, Katherine; Haughey, Norman; Turchan-Cholewo, Jadwiga; Hahn, Katrin; Rosen, Antony; Steiner, Joseph; Keswani, Sanjay; Jones, Melina; Calabresi, Peter A.; Nath, Avindra
- Abstract
Discusses research which determined whether activated T cells release soluble factors such as granzyme B (GrB)participate in T cell-induced neurotoxicity; Mechanisms underlying the GrB-mediated neurotoxicity; downstream events involved in GrB-mediated neuronal cell death; Role played by T cell activation in the pathogenesis of multiple sclerosis and other neuroinflammatory diseases.
- Subjects
T cells; NEUROTOXICOLOGY; CELL death; MULTIPLE sclerosis; MEDICAL research
- Publication
FASEB Journal, 2006, Vol 20, Issue 8, p1209
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-5022fje