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- Title
Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised.
- Authors
Warskulat, Ulrich; Flögel, Ulrich; Jacoby, Christoph; Hartwig, Hans-Georg; Thewissen, Michael; Merx, Marc W.; Molojavyi, Andrej; Heller-Stilb, Birgit; Schrader, Jürgen; Häussinger, Dieter
- Abstract
Identifies taurine transport as a crucial factor for the maintenance of skeletal muscle function and total exercise capacity while cardiac muscle can compensate for the loss of taurine. Taurine transporter gene knockout; Analysis of taut-/- skeletal muscle; Upregulation of the cytosolic concentration of several organic solutes in heart but not in skeletal muscle.
- Subjects
TAURINE; MUSCLES; EXERCISE; MYOCARDIUM; HEART
- Publication
FASEB Journal, 2004, Vol 18, Issue 3, p577
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.03-0496fje