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- Title
動物実験によらない免疫毒性評価の国際動向 ―新方式の開発に向けて―.
- Authors
小島 肇夫; 足利 太可雄
- Abstract
We have ongoing projects that are developing New Approach Methods (NAMs) for systematic toxicology. One NAM is to develop the immunotoxicity evaluation with non-animal test methods for the Organisation for Economic Co-operation and Development (OECD)Test Guideline (TG). The development of this evaluation includes the following steps: 1) adverse outcome pathway (AOP), 2) detailed review paper, 3) test methods based on AOP, 4) validation study of test methods for developing TGs, and 5) integrated approaches to testing and assessment (IATA). I believe that the NAMs developed on these steps may enable risk assessment of a chemical with non-animal test methods in near future.
- Subjects
ORGANISATION for Economic Co-operation &; Development; TEST methods; CHEMICAL testing; IMMUNOTOXICOLOGY; ECONOMIC development; RISK assessment
- Publication
Folia Pharmacologica Japonica, 2022, Vol 157, Issue 5, p340
- ISSN
0015-5691
- Publication type
Article
- DOI
10.1254/fpj.22036