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- Title
VITAMINA D Y COLONIZACIONES PULMONARES CRÓNICAS EN PACIENTES PEDIÁTRICOS Y ADULTOS JÓVENES CON FIBROSIS QUÍSTICA.
- Authors
González Jiménez, David; Muñoz Codoceo, Rosana; Garriga García, María; Molina Arias, Manuel; Álvarez Beltrán, Marina; García Romero, Ruth; Martínez Costa, Cecilia; Meavilla Olivas, Silvia María; Peña Quintana, Luis; Gallego Gutiérrez, Silvia; Marugán de Miguelsanz, José Manuel; Suárez Cortina, Lucrecia; Castejón Ponce, Esperanza Natividad; Trabazo, Rosaura Leis; Cruz, Fayna Martín; Díaz Martin, Juan José; Bousoño García, Carlos; Alvarez Beltran, Marina; Gallego Gutierrez, Silvia; Marugan de Miguelsanz, Jose Manuel
- Abstract
<bold>Introduction and Objectives: </bold>evaluate vitamin D status and its association with chronic lung colonisation in Cystic Fibrosis patients.<bold>Material and Methods: </bold>descriptive cross-sectional multicenter study. From November 2012 to April 2014, at 12 national hospitals, 377 patients with Cystic Fibrosis were included. Vitamin D levels < 30 ng/ml were classified as insufficient. Chronic colonisation was considered if they had at least two positive cultures in the past year.<bold>Results: </bold>the median age was 8.9 years (2 months to 20 years). 65% had insufficient levels of vitamin D. There was an inverse correlation between age and vitamin D levels (r = -0.20 p < 0.001). Those diagnosed by screening, were younger and had higher levels of vitamin D. There was an inverse correlation between the number of colonisations and vitamin D levels (r = -0.16 p = 0.0015). Adjusting for age, pancreatic status and diagnosis by screening, colonization by S. aureus in 6 years, increased the risk of insufficient levels of vitamin D: OR 3.17 (95% CI 1.32 to 7.61) (p = 0.010) and OR 3.77 (95% CI 1.37 to 10 , 37) (p = 0.010), respectively.<bold>Conclusions: </bold>despite adequate supplementation, more than half of our patients did not achieve optimal levels of vitamin D. Regardless of age, diagnosis by screening or pancreatic status, chronic colonization by Pseudomonas sp. in children and adolescents and S. Aureus in infants and preschoolars increases the risk of developing vitamin D deficiency in these patients.
- Subjects
LUNG microbiology; THERAPEUTIC use of vitamin D; VITAMIN therapy; COMPARATIVE studies; CYSTIC fibrosis; RESEARCH methodology; MEDICAL cooperation; RESEARCH; VITAMIN D; VITAMIN D deficiency; EVALUATION research; CROSS-sectional method; DISEASE complications
- Publication
Nutrición Hospitalaria, 2015, Vol 32, Issue 4, p1629
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.3305/nh.2015.32.4.9503