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- Title
BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling.
- Authors
Huynh, Do Luong; Koh, Hyebin; Chandimali, Nisansala; Zhang, Jiao Jiao; Kim, Nameun; Kang, Tae Yoon; Ghosh, Mrinmoy; Gera, Meeta; Park, Yang-Ho; Kwon, Taeho; Jeong, Dong Kee
- Abstract
Pancreatic cancer has a poor survival rate as compared to other types of cancer. Surface marker CD44 plays important role in epithelial-mesenchymal transition and cancer stem cell phenotype. Therefore, targeting CD44 positive pancreatic cancer cells might enhance therapies effectiveness. Our previous studies indicated the antitumorigenesis effect of BRM270 in osteosarcoma, lung cancer, and glioblastoma; however there is no evidence on BRM270 impacts on pancreatic cancer growth. In this study, we investigated the effect of BRM270 on the isolated CD44 positive pancreatic ductal adenocarcinoma cells (CD44+ PDAC). Results showed that CD44 positive cells undergo apoptosis induced by BRM270. Moreover, BRM270 also inhibits stemness and metastasis traits in CD44+ PDAC via Sonic hedgehog signaling pathway and SALL4 expression. In vivo study indicated that tumor growth derived from CD44+ PDAC was suppressed as daily uptake by BRM270 5 mg/kg. These data suggest the alternative approach in antipancreatic tumorigenesis via herbal plants extract and selectively targeting CD44+ PDAC cells in tumor.
- Subjects
CELL proliferation; ADENOCARCINOMA; ANIMAL experimentation; APOPTOSIS; CELL lines; CELLULAR signal transduction; GENE expression; HERBAL medicine; METASTASIS; MICE; PANCREATIC tumors; PLANT extracts; DUCTAL carcinoma; IN vivo studies
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2019, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2019/8620469