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- Title
Preparation of Ca-alginate biopolymer beads and investigation of their decorporation characteristics for 85Sr, 238U and 234Th by in vitro experiments.
- Authors
Gok, Cem; Gerstmann, Udo; Höllriegl, Vera; Aytas, Sule
- Abstract
The aim of this work was to investigate whether Ca-alginate biopolymer beads (CaABBs) can be used to reduce the bioavailability of radionuclides in the gastrointestinal tract of humans. The uptake of strontium, uranium and thorium from a simulated gastrointestinal system was studied by in vitro techniques using CaABBs. This agent was prepared from Na-alginate through cross-linking with divalent calcium ions according to the egg-box model. The effects of process variables such as pH of the gastrointestinal juice, incubation time and solid-to-solution ratio for the removal of radionuclides from the gastrointestinal juice were investigated. The results suggest that CaABBs are a potent material for reducing the bioavailability of radionuclides with a high uptake efficiency in the gastrointestinal tract.
- Subjects
ALGINATES; BIOPOLYMERS; BIOAVAILABILITY; RADIOISOTOPES; CALCIUM ions; GASTRIC acid
- Publication
Radiation Protection Dosimetry, 2013, Vol 153, Issue 1, p47
- ISSN
0144-8420
- Publication type
Article
- DOI
10.1093/rpd/ncs088