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- Title
Moderate alcohol consumption and atherosclerosis.
- Authors
Huang, Yunying; Li, Yongmei; Zheng, Sichao; Yang, Xin; Wang, Tenghua; Zeng, Jie
- Abstract
Objective: Alcohol consumption plays an important role in the risk of major cardiovascular diseases. We conducted a meta-analysis to summarize the association between moderate alcohol consumption and atherosclerosis. Design: In this study four databases and reference lists of retrieved articles were searched to identify eligible studies. A meta-analysis was carried out of all interventional studies that assessed the effects of moderate alcohol consumption on concentrations of low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, apolipoprotein A I, interleukin 6, plasminogen activator inhibitor 1, fibrinogen, and other biomarkers previously found to be associated with risk of atherosclerosis. Results: A total of 31 studies met the eligibility criteria. In response to moderate alcohol consumption, low density lipoprotein cholesterol decreased by 0.08 mmol/l ( P = 0.05), and high density lipoprotein cholesterol increased by 0.08 mmol/l ( P < 0.00001), whereas total cholesterol and triglyceride remained the same. Moreover, interleukin 6 decreased by 0.43 pg/ml ( P = 0.03), whereas C-reactive protein and tumor necrosis factor a remained the same. Several hemostatic factors and adiponectin were modestly affected by alcohol consumption. Conclusion: Moderate alcohol consumption is causally related to lower risk of atherosclerosis through changes in lipid profiles and inflammation.
- Subjects
ALCOHOL drinking; ATHEROSCLEROSIS; APOLIPOPROTEIN A; BIOMARKERS; HIGH density lipoproteins; META-analysis
- Publication
Wiener Klinische Wochenschrift, 2017, Vol 129, Issue 21/22, p835
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-017-1235-6