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- Title
The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy
- Authors
Matsumoto, Hirokazu; Maruse, Hideaki; Inaba, Yumi; Yoshizawa, Kanako; Sasazaki, Shinji; Fujiwara, Akira; Nishibori, Masahide; Nakamura, Akinori; Takeda, Shin’ichi; Ichihara, Nobutsune; Kikuchi, Tateki; Mukai, Fumio; Mannen, Hideyuki
- Abstract
Abstract: Chicken muscular dystrophy with abnormal muscle (AM) has been studied for more than 50 years, but the gene responsible for it remains unclear. Our previous studies narrowed down the AM candidate region to approximately 1Mbp of chicken chromosome 2q containing seven genes. In this study, we performed sequence comparison and gene expression analysis to elucidate the responsible gene. One missense mutation was detected in AM candidate genes, while no remarkable alteration of expression patterns was observed. The mutation was identified in WWP1, detected only in dystrophic chickens within several tetrapods. These results suggested WWP1 is responsible for chicken muscular dystrophy.
- Subjects
MUSCULAR dystrophy; CHICKEN diseases; GENE expression; GENETIC mutation
- Publication
FEBS Letters, 2008, Vol 582, Issue 15, p2212
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.05.013