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- Title
Interventional Closure of Secundum Type Atrial Septal Defects in Infants Less Than 10 Kilograms: Indications and Procedural Outcome.
- Authors
Wyss, Yves; Quandt, Daniel; Weber, Roland; Stiasny, Brian; Weber, Benedikt; Knirsch, Walter; Kretschmar, Oliver
- Abstract
<bold>Aims: </bold>This study set out to assess indications, feasibility, complications, and clinical outcome of percutaneous transcatheter device closure of atrial septal defects (ASDs) in infants with a bodyweight below 10 kg.<bold>Methods and Results: </bold>Retrospective single center chart and echocardiography review study from 8/2005-12/2013. Twenty-eight children with ASD (13 female) with a median age of 1.15 years (0.2-2.8) and a median weight of 7.2 kg (4.5-9.9) were analyzed. Indications for early ASD closure were failure to thrive (n = 15, 54%), bronchopulmonary dysplasia (BPD) with supplemental oxygen dependency (n = 7, 25%), and genetic syndromes with suspected pulmonary hypertension (n = 12, 43%). Device implantation was successful in all patients without any periprocedural mortality or major complication. Clinical outcome after a median follow-up period of 2.1 years (0.25-7.3) revealed no residual shunt and a significant decrease of right ventricular volume load. Patients with pulmonary hypertension experienced a significant reduction of pulmonary artery/RV pressure. Patients also showed decreased supplemental oxygen dependency and less cardiac medications, but no significant "catch-up growth" in those with failure to thrive.<bold>Conclusion: </bold>Interventional ASD closure in children weighing less than 10 kg can be performed without any additional major risks and shows a favorable outcome, especially in selected patients with significant non cardiac co-morbidities.
- Subjects
ATRIAL septal defects in children; ATRIAL septal defect treatment; HEART septum abnormalities; EISENMENGER syndrome; HOLT-Oram syndrome
- Publication
Journal of Interventional Cardiology, 2016, Vol 29, Issue 6, p646
- ISSN
0896-4327
- Publication type
journal article
- DOI
10.1111/joic.12328