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- Title
Risk factors for cerebral palsy in neonates due to placental abruption.
- Authors
Ichizuka, Kiyotake; Toyokawa, Satoshi; Ikenoue, Tsuyomu; Satoh, Shoji; Hasegawa, Junichi; Ikeda, Tomoaki; Tamiya, Nanako; Nakai, Akihito; Fujimori, Keiya; Maeda, Tsugio; Kanayama, Naohiro; Masuzaki, Hideaki; Iwashita, Mitsutoshi; Suzuki, Hideaki; Takeda, Satoru
- Abstract
Aim: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. Methods: A retrospective case–control study was conducted using a nationwide registry from Japan. The study population included pregnant women (n = 122) who delivered an infant with CP between 2009 and 2015, where placental abruption was identified as the single cause of CP. The control group consisted of pregnant women with placental abruption, who delivered an infant without CP and were managed from 2013 to 2014. They were randomly identified from the prenatal database of the Japan Society of Obstetrics and Gynecology (JSOG‐DB; n = 1214). Risk factors were investigated using multivariate analysis. Results: Alcohol consumption (3.38, 2.01–5.68) (odds ratio, 95% confidence interval), smoking during pregnancy (3.50, 1.32–9.25), number of deliveries (1.28, 1.05–1.56), polyhydramnios (5.60, 1.37–22.6), oral administration of ritodrine hydrochloride (2.09, 1.22–3.57) and hypertensive disorders in pregnancy (2.25, 1.27–4.07) were significant risk factors. In contrast, intravenous administration of oxytocin (odds ratio, 95% confidence interval: 0.22, 0.09–0.58) and magnesium sulfate (0.122, 0.02–0.89) attenuated risk. Conclusion: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption. Regarding alcohol consumption and smoking during pregnancy, the results suggest the importance of educational activities targeting pregnant women to increase their awareness of placental abruption.
- Subjects
JAPAN; CEREBRAL palsy; CONFIDENCE intervals; ALCOHOL drinking; HYPERTENSION; NEONATAL diseases; MAGNESIUM sulfate; MOTHERS; MULTIVARIATE analysis; OXYTOCIN; RITODRINE; SMOKING; RETROSPECTIVE studies; CASE-control method; POLYHYDRAMNIOS; ABRUPTIO placentae; ODDS ratio; DISEASE risk factors; PREGNANCY
- Publication
Journal of Obstetrics & Gynaecology Research, 2021, Vol 47, Issue 1, p159
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.14447