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- Title
A Ruthenium Complex-Catalyzed Cyclotrimerization of Halodiynes with Nitriles. Synthesis of 2- and 3-Halopyridines.
- Authors
Bednářová, Eva; Colacino, Evelina; Lamaty, Frédéric; Kotora, Martin
- Abstract
Monohalo- and dihalodiynes efficiently undergo [2+2+2] cyclotrimerization with nitriles in the presence of a catalytic amount of the ruthenium complex Cp*RuCl(cod) (10 mol%) to afford the corresponding halopyridines under ambient conditions in good isolated yields (up to 90%). The halopyridines are formed as two separable regioisomers. This is the first example of a direct synthesis of halopyridines from haloalkynes and nitriles.
- Subjects
ALKYNES; NITRILE synthesis; HOMOGENEOUS catalysis; HETEROCYCLIC compounds; RUTHENIUM
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 12, p1916
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201600127