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- Title
Photo‐Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles.
- Authors
Perez Schmidt, Patricia; Pagano, Katiuscia; Lenardi, Cristina; Penconi, Marta; Ferrando, Ruth Mateu; Evangelisti, Claudio; Lay, Luigi; Ragona, Laura; Marelli, Marcello; Polito, Laura
- Abstract
Ultra‐small gold nanoparticles (UAuNPs) are extremely interesting for applications in nanomedicine thanks to their good stability, biocompatibility, long circulation time and efficient clearance pathways. UAuNPs engineered with glycans (Glyco‐UAuNPs) emerged as excellent platforms for many applications since the multiple copies of glycans can mimic the multivalent effect of glycoside clusters. Herein, we unravel a straightforward photo‐induced synthesis of Glyco‐UAuNPs based on a reliable and robust microfluidic approach. The synthesis occurs at room temperature avoiding the use of any further chemical reductant, templating agents or co‐solvents. Exploiting 1H NMR spectroscopy, we showed that the amount of thiol‐ligand exposed on the UAuNPs is linearly correlated to the ligand concentration in the initial mixture. The results pave the way towards the development of a programmable synthetic approach, enabling an accurate design of the engineered UAuNPs or smart hybrid nano‐systems.
- Subjects
GOLD nanoparticles; NUCLEAR magnetic resonance spectroscopy; GLYCANS; NANOMEDICINE; PHOTOTHERMAL effect
- Publication
Angewandte Chemie, 2023, Vol 135, Issue 1, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202210140