We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Paneth hücreleri ve mukozal immünite.
- Authors
Özatik, Orhan
- Abstract
Paneth cells constitute the crypts of small intestines together with columnar, goblet and enteroendocrine cells. Their count in the crypts gradually increases towards the distal regions, with being most abundant in the terminal ileum. According to a more recent hypothesis, antibiotic peptides are released form intestinal epithelial cells and these peptides are considered as the components of mucosal immunity. In mammalian small intestine, paneth ceils secrete alpha defensin and additional antimicrobial peptide-containing granules into the lumen between crypts. Alpha defensins are in the same class with nonoxidative microbial cell killer peptides in the phagocytic leukocytes and these effects were also shown in in vitro studies. Any injury of the crypts and induction of paneth cell insufficiency are compensated with accumulation of cells from crypt centers and release of antimicrobial substances from paneth cells.
- Subjects
MUCOUS membranes; EPITHELIAL cells; PEPTIDE drugs; LEUCOCYTES; ANTI-infective agents; CELLULAR immunity; SMALL intestine diseases
- Publication
Medical Journal of Suleyman Demirel University, 2011, Vol 18, Issue 1, p30
- ISSN
1300-7416
- Publication type
Article