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- Title
Phase-based arterial input function measurements in the femoral arteries for quantification of dynamic contrast-enhanced (DCE) MRI and comparison with DCE-CT.
- Authors
Korporaal, Johannes G.; van den Berg, Cornelis A. T.; van Osch, Matthias J. P.; Groenendaal, Greetje; van Vulpen, Marco; van der Heide, Uulke A.
- Abstract
Dynamic contrast-enhanced (DCE) MRI is useful for diagnosis, treatment monitoring and follow-up of prostate cancer. However, large differences have been reported in the parameter range of the transfer constant Ktrans, making longitudinal studies and comparison of DCE-MRI findings between studies difficult. Large part of this inconsistency in Ktrans values can be attributed to problems with the accurate measurement of the arterial input function (AIF) from the magnitude signal (AIFMAGN). Phase-based AIF measurements (AIFPHASE) have been proposed as a more robust alternative to AIFMAGN measurements. This study compares AIFPHASE with AIFs measured with DCE-CT (AIFCT), and the corresponding Ktrans maps in 12 prostate cancer patients. The shape of AIFPHASE and AIFCT are similar, although differences in the peak height and peak width exist as a result of differences in injection protocol. No significant differences in Ktrans values were found between the DCE-MRI and DCE-CT exams, with median Ktrans values of 0.10 and 0.08 min−1 for healthy peripheral zone tissue and 0.44 and 0.36 min−1 for regions suspected of tumor respectively. Therefore, robust quantification of Ktrans values from DCE-MRI exams in the cancerous prostate is feasible with the use of AIFPHASE. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2011, Vol 66, Issue 5, p1267
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.22905