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TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes.
Published in:
International Immunology, 2007, v. 19, n. 9, p. 1115
By:
- Liesbeth E. M. Oosten;
- Danijela Koppers-Lalic;
- Els Blokland;
- Arend Mulder;
- Maaike E. Ressing;
- Tuna Mutis;
- Astrid G. S. van Halteren;
- Emmanuel J. H. J. Wiertz;
- Els Goulmy
Publication type:
Article
Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.
Published in:
International Immunology, 2006, v. 18, n. 1, p. 173, doi. 10.1093/intimm/dxh362
By:
- Martine T. Barel;
- Nathalie Pizzato;
- Philippe Le Bouteiller;
- Emmanuel J. H. J. Wiertz;
- Francoise Lenfant
Publication type:
Article
Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2.
Published in:
PLoS ONE, 2024, v. 19, n. 5, p. 1, doi. 10.1371/journal.pone.0287877
By:
- Cremer, Tom;
- Hoelen, Hanneke;
- van de Weijer, Michael L.;
- Janssen, George M.;
- Costa, Ana I.;
- van Veelen, Peter A.;
- Lebbink, Robert Jan;
- Wiertz, Emmanuel J. H. J.
Publication type:
Article
A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape.
Published in:
Scientific Reports, 2017, p. 41968, doi. 10.1038/srep41968
By:
- Lebbink, Robert Jan;
- de Jong, Dorien C. M.;
- Wolters, Femke;
- Kruse, Elisabeth M.;
- van Ham, Petra M.;
- Wiertz, Emmanuel J. H. J.;
- Nijhuis, Monique
Publication type:
Article
Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0128206
By:
- Hoelen, Hanneke;
- Zaldumbide, Arnaud;
- van Leeuwen, Wouter F.;
- Torfs, Ellen C. W.;
- Engelse, Marten A.;
- Hassan, Chopie;
- Lebbink, Robert Jan;
- de Koning, Eelco J.;
- Resssing, Maaike E.;
- de Ru, Arnoud H.;
- van Veelen, Peter A.;
- Hoeben, Rob C.;
- Roep, Bart O.;
- Wiertz, Emmanuel J. H. J.
Publication type:
Article
TAP Mediates Import of <i>Mycobacterium tuberculosis</i>-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I.
Published in:
PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079571
By:
- Harriff, Melanie J.;
- Burgdorf, Sven;
- Kurts, Christian;
- Wiertz, Emmanuel J. H. J.;
- Lewinsohn, Deborah A.;
- Lewinsohn, David M.
Publication type:
Article
Adenoviral Vectors Stimulate Glucagon Transcription in Human Mesenchymal Stem Cells Expressing Pancreatic Transcription Factors.
Published in:
PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0048093
By:
- Zaldumbide, Arnaud;
- Carlotti, Françoise;
- Gonçalves, Manuel A.;
- Knaän-Shanzer, Shoshan;
- Cramer, Steve J.;
- Roep, Bart O.;
- Wiertz, Emmanuel J. H. J.;
- Hoeben, Rob C.
Publication type:
Article
Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants.
Published in:
PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0014493
By:
- de la Garza-Rodea, Anabel S.;
- Verweij, Marieke C.;
- Boersma, Hester;
- van der Velde-van^Dijke, Ietje;
- de Vries, Antoine A. F.;
- Hoeben, Rob C.;
- van Bekkum, Dirk W.;
- Wiertz, Emmanuel J. H. J.;
- Knaän-Shanzer, Shoshan
Publication type:
Article
Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines.
Published in:
BMC Genomics, 2016, v. 17, p. 1, doi. 10.1186/s12864-016-2978-6
By:
- Hooykaas, Marjolein J. G.;
- Kruse, Elisabeth;
- Wiertz, Emmanuel J. H. J.;
- Lebbink, Robert Jan
Publication type:
Article
Ion trap multiple-stage tandem mass spectrometry as a pre-NMR tool in the structure elucidation of saponins.
Published in:
Phytochemical Analysis, 2000, v. 11, n. 3, p. 190, doi. 10.1002/(SICI)1099-1565(200005/06)11:3<190::AID-PCA512>3.0.CO;2-2
By:
- van Setten, Dirk C;
- Zomer, Gijsbert;
- Werken, Gerrit van de;
- Wiertz, Emmanuel J H J;
- Leeflang, Bas R;
- Kamerling, Johannis P
Publication type:
Article
Varicellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP.
Published in:
PLoS Pathogens, 2008, v. 4, n. 5, p. 1, doi. 10.1371/journal.ppat.1000080
By:
- Koppers-Lalic, Danijela;
- Verweij, Marieke C.;
- Lipińska, Andrea D.;
- Ying Wang;
- Quinten, Edwin;
- Reits, Eric A.;
- Koch, Joachim;
- Loch, Sandra;
- Rezende, Marisa Marcondes;
- Daus, Franz;
- Bieńkowska-Szewczyk, Krystyna;
- Osterrieder, Nikolaus;
- Mettenleiter, Thomas C.;
- Heemskerk, Mirjam H. M.;
- Tampé, Robert;
- Neefjes, Jacques J.;
- Chowdhury, Shafiqul I.;
- Ressing, Maaike E.;
- Rijsewijk, Frans A. M.;
- Wiertz, Emmanuel J. H. J.
Publication type:
Article
The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein.
Published in:
Viruses (1999-4915), 2016, v. 8, n. 11, p. 309, doi. 10.3390/v8110309
By:
- Van De Weijer, Michael L.;
- Van Muijlwijk, Guus H.;
- Visser, Linda J.;
- Costa, Ana I.;
- Wiertz, Emmanuel J. H. J.;
- Lebbink, Robert Jan
Publication type:
Article
CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections.
Published in:
PLoS Pathogens, 2016, v. 12, n. 6, p. 1, doi. 10.1371/journal.ppat.1005701
By:
- van Diemen, Ferdy R.;
- Kruse, Elisabeth M.;
- Hooykaas, Marjolein J. G.;
- Bruggeling, Carlijn E.;
- Schürch, Anita C.;
- van Ham, Petra M.;
- Imhof, Saskia M.;
- Nijhuis, Monique;
- Wiertz, Emmanuel J. H. J.;
- Lebbink, Robert Jan
Publication type:
Article
The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells.
Published in:
PLoS Pathogens, 2016, v. 12, n. 4, p. 1, doi. 10.1371/journal.ppat.1005550
By:
- Gram, Anna M.;
- Oosenbrug, Timo;
- Lindenbergh, Marthe F. S.;
- Büll, Christian;
- Comvalius, Anouskha;
- Dickson, Kathryn J. I.;
- Wiegant, Joop;
- Vrolijk, Hans;
- Lebbink, Robert Jan;
- Wolterbeek, Ron;
- Adema, Gosse J.;
- Griffioen, Marieke;
- Heemskerk, Mirjam H. M.;
- Tscharke, David C.;
- Hutt-Fletcher, Lindsey M.;
- Wiertz, Emmanuel J. H. J.;
- Hoeben, Rob C.;
- Ressing, Maaike E.
Publication type:
Article
Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution.
Published in:
PLoS Pathogens, 2015, v. 11, n. 4, p. 1, doi. 10.1371/journal.ppat.1004743
By:
- Verweij, Marieke C.;
- Horst, Daniëlle;
- Griffin, Bryan D.;
- Luteijn, Rutger D.;
- Ressing, Maaike E.;
- Wiertz, Emmanuel J. H. J.;
- Davison, Andrew J.
Publication type:
Article
Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle.
Published in:
PLoS Pathogens, 2009, v. 5, n. 6, p. 1, doi. 10.1371/journal.ppat.1000490
By:
- Croft, Nathan P.;
- Shannon-Lowe, Claire;
- Bell, Andrew I.;
- Horst, Daniëlle;
- Kremmer, Elisabeth;
- Ressing, Maaike E.;
- Wiertz, Emmanuel J. H. J.;
- Middeldorp, Jaap M.;
- Rowe, Martin;
- Rickinson, Alan B.;
- Hislop, Andrew D.
Publication type:
Article
The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation.
Published in:
PLoS Pathogens, 2009, v. 5, n. 1, p. 1, doi. 10.1371/journal.ppat.1000255
By:
- Jianmin Zuo;
- Currin, Andrew;
- Griffin, Bryan D.;
- Shannon-Lowe, Claire;
- Thomas, Wendy A.;
- Ressing, Maaike E.;
- Wiertz, Emmanuel J. H. J.;
- Rowe, Martin
Publication type:
Article
Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.
Published in:
Journal of Cell Biology, 2009, v. 187, n. 5, p. 655, doi. 10.1083/jcb.200908036
By:
- Xiaoli Wang;
- Herr, Roger A.;
- Rabelink, Martijn;
- Hoeben, Rob C.;
- Wiertz, Emmanuel J. H. J.;
- Hansen, Ted H.
Publication type:
Article
The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.
Published in:
Journal of Cell Biology, 2009, v. 186, n. 5, p. 685, doi. 10.1083/jcb.200906110
By:
- Stagg, Helen R.;
- Thomas, Mair;
- van den Boomen, Dick;
- Wiertz, Emmanuel J. H. J.;
- Drabkin, Harry A.;
- Gemmill, Robert M.;
- Lehner, Paul J.
Publication type:
Article
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.
Published in:
Journal of Cell Biology, 2007, v. 177, n. 4, p. 613, doi. 10.1083/jcb.200611063
By:
- Wang, Xiaoli;
- Herr, Roger A.;
- Chua, Wei-Jen;
- Lybarger, Lonnie;
- Wiertz, Emmanuel J. H. J.;
- Hansen, Ted H.
Publication type:
Article
Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression.
Published in:
Scientific Reports, 2015, p. 12748, doi. 10.1038/srep12748
By:
- Benedictus, Lindert;
- Luteijn, Rutger D.;
- Otten, Henny;
- Jan Lebbink, Robert;
- van Kooten, Peter J. S.;
- Wiertz, Emmanuel J. H. J.;
- Rutten, Victor P. M. G.;
- Koets, Ad P.
Publication type:
Article
A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope.
Published in:
Cells (2073-4409), 2020, v. 9, n. 9, p. 1989, doi. 10.3390/cells9091989
By:
- Luteijn, Rutger D.;
- Praest, Patrique;
- Thiele, Frank;
- Sadasivam, Saravanan Manikam;
- Singethan, Katrin;
- Drijfhout, Jan W.;
- Bach, Christian;
- de Boer, Steffen Matthijn;
- Lebbink, Robert J.;
- Tao, Sha;
- Helfer, Markus;
- Bach, Nina C.;
- Protzer, Ulrike;
- Costa, Ana I.;
- Killian, J. Antoinette;
- Drexler, Ingo;
- Wiertz, Emmanuel J. H. J.
Publication type:
Article
Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter.
Published in:
Cells (2073-4409), 2019, v. 8, n. 12, p. 1590, doi. 10.3390/cells8121590
By:
- Wąchalska, Magda;
- Graul, Małgorzata;
- Praest, Patrique;
- Luteijn, Rutger D.;
- Babnis, Aleksandra W.;
- Wiertz, Emmanuel J. H. J.;
- Bieńkowska-Szewczyk, Krystyna;
- Lipińska, Andrea D.
Publication type:
Article
Endocytosed soluble cowpox virus protein CPXV012 inhibits antigen cross‐presentation in human monocyte‐derived dendritic cells.
Published in:
Immunology & Cell Biology, 2018, v. 96, n. 2, p. 137, doi. 10.1111/imcb.1024
By:
- Spel, Lotte;
- Luteijn, Rutger D.;
- Drijfhout, Jan W.;
- Nierkens, Stefan;
- Boes, Marianne;
- Wiertz, Emmanuel J. H.
Publication type:
Article
Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls.
Published in:
Immunology & Cell Biology, 2011, v. 89, n. 3, p. 359, doi. 10.1038/icb.2010.129
By:
- Horst, Daniëlle;
- Ressing, Maaike E.;
- Wiertz, Emmanuel J. H. J.
Publication type:
Article
Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation.
Published in:
European Journal of Immunology, 2003, v. 33, n. 6, p. 1707, doi. 10.1002/eji.200323912
By:
- Barel, Martine T.;
- Pizzato, Nathalie;
- van Leeuwen, Daphne;
- Bouteiller, Philippe Le;
- Wiertz, Emmanuel J. H. J.;
- Lenfant, Francoise
Publication type:
Article

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