We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinctive IGHV gene usage and stereotyped receptors in South American patients with chronic lymphocytic leukemia.
- Authors
Stanganelli, Carmen; Torres, Davi Coe; Ortega, Claudia; Sotelo, Natalia; Márquez, María Elena; Segges, Priscilla; Muniz, María Tereza C.; Bigni, Ricardo S.; Campregher, Paulo V.; Sabino, Adriano; Gomes, Caio Perez; Lopes Ferrari deChauffaille, María Lourdes; Arrais Rodrigues, Celso; Yamamoto, Mihoko; Abdelhay, Eliana; Cabrera, Juana; Deglesne, Pierre‐Antoine; López, José Luis; Galvano, Camila; Krzywinski, Andrea
- Abstract
The IGHV ( I immunoglobulin heavy-chain variable region i ) mutational status is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL), the most frequent adult leukemia in the Western World. CLL patients from Venezuela showed the highest IGHV3-21 rates, similar to those observed in Scandinavian series,[6] with differences compared with Brazil and Uruguay ( I P i <.02). (II) Distribution of chronic lymphocytic leukemia (CLL) patients with 0-1 FISH alterations compared with those with >=2 FISH alterations. Table S4: IGHV family usage in CLL patients from different geographic regionsTable S5: Frequency of IGHV gene usage in CLL patients from South American countries.
- Subjects
CHRONIC lymphocytic leukemia; B cell receptors; IMMUNOGLOBULIN heavy chains; GENETIC mutation; SOUTH Americans
- Publication
Hematological Oncology, 2019, Vol 37, Issue 5, p644
- ISSN
0278-0232
- Publication type
Article
- DOI
10.1002/hon.2661